Is Squalane More Hydrating Than Hyaluronic Acid? Dermatologist Review
In the world of skincare, there are a lot of hydrating ingredients to consider, like glycerin and oils. However, hyaluronic acid and squalane have quickly become a sensation—and for good reason. Both are found in everything from serums to face washes, moisturizers, makeup, and more, and are touted for their lightweight feel and ability to work in harmony with the skin’s natural barrier.
Although the two may seem similar at first glance, hyaluronic acid and squalane have different properties and functions that set them apart from one another. Depending on your needs, you may find that one or the other fits your routine better. To answer all of your burning questions about squalane vs. hyaluronic acid, and to help you decide which is best for your skin type, we turned to board-certified dermatologists Rebecca Marcus, MD, and Blair Murphy-Rose, MD, FAAD, with their savvy.
Read on to learn all about squalane and hyaluronic acid.
Meet the Experts
Rebecca Marcus, MD, is a board-certified dermatologist in Dallas, Texas, and founder of Maei MD, a skincare brand focused on creating worry-free, nourishing products that promote radiant, healthy-looking skin.
Blair Murphy-Rose, MD, FAAD, is a board-certified cosmetic and medical dermatologist at the New York Center for Laser and Skin Surgery, specializing in facial rejuvenation. She is also a clinical instructor in dermatology at Weill Cornell Medical College.
What is Squalane?
Squalane is a laboratory-developed hydrogenated form of squalene, which is a “naturally occurring lipid component of sebum that moisturizes the skin,” Murphy-Rose says. “Squalane is an emollient that softens and moisturizes the skin and helps retain moisture in the skin. [It] protects and supports the skin barrier and has antioxidant properties that reverse and prevent free radical damage.” ”
If you’re wondering how squalane differs from squalene, Murphy-Rose explains that the former is designed to harness the skin-boosting benefits of squalene while making it more shelf-stable. This means squalane is better suited for use in skin care, as squalene is an unstable molecule. The natural production of squalene decreases as we age, so if you find your skin getting drier over time, these ingredients may help. “Squalane is also lighter than squalene, so unlike squalene, it’s better suited for acne-prone skin,” Murphy-Rose adds.
What is hyaluronic acid?
Hyaluronic acid is a hydrating molecule that attracts and retains water in the skin. “It’s a natural component of the skin, eyes, and joints, where it acts as a humectant, or a substance that draws water into the skin,” Marcus says.
Hyaluronic acid has an immediate plumping effect on the skin and can reduce the appearance of fine lines. This makes the hydrophilic ingredient very popular, and you may have seen brands touting their hyaluronic acid serums or moisturizers as containing the powerful yet gentle acid.
Squalane vs. Hyaluronic Acid: The Difference
Murphy-Ross tells us the main difference between squalane and hyaluronic acid is their chemical makeup and the way they hydrate the skin. Here’s a little science lesson to explain it: “Squalane is a lipid and hyaluronic acid is a glycosaminoglycan (basically a chain of sugar molecules),” Marcus says. “Hyaluronic acid is a humectant, which draws water into the skin, while squalene is an emollient, which means it acts as a barrier, locking water into the skin.”
Despite their different modes of action, that doesn’t mean the two ingredients don’t have a lot in common. “Both help keep the skin healthy and hydrated,” Murphy-Ross says. “Both are hypoallergenic and generally good for sensitive skin.” ”
“Both are hydrating molecules that help boost skin moisture levels,” adds Marcus. “Both occur naturally in the body. Well, almost—squalene is naturally occurring, while squalane is a chemically modified form.”
Which one, squalane or hyaluronic acid, is better for you is up to you. “Both are very effective ingredients that are suitable for all skin types, including sensitive skin,” says Murphy-Ross. “Hyaluronic acid is great for hydrating oily or acne-prone skin because it’s lightweight and brings moisture to the surface of the skin without clogging pores. Squalane is a very effective ingredient for hydrating dry skin, but can also be used in formulas that won’t aggravate acne.” ”
How often you should apply depends on the type of product, such as a serum, lotion, or moisturizer, but Murphy-Rose generally recommends using it once or twice a day. “Both work well in creams and lotions,” she says.
Can squalane and hyaluronic acid be used together?
Yes, you can use both squalane and hyaluronic acid, either by layering separate products or trying a formula that contains both. “If used alone, hyaluronic acid should be used first because it draws moisture into the skin,” Marcus advises. “Adding squalane creates a barrier that retains moisture in the skin and prevents it from evaporating.”
The Bottom Line
Ultimately, hyaluronic acid and squalane are standout ingredients in skincare products that are beneficial for most skin types. Because each ingredient helps restore the skin’s natural hydration process, both are great choices if you’re battling dryness or dehydration—just make sure you find a formula that works for your overall skin type. “Both are great for dry skin, acne-prone skin, inflamed skin, and even sensitive skin,” Marcus says. “It really comes down to personal preference.”
